Relationship with Bipolar Temperament and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease

Objects: To evaluate the relationship between bipolar temperament (BT) and the behavioral and psychological symptoms of dementia (BPSD) in Alzheimer’s disease (AD). Backgrounds: In Japan, no medicine is permitted for BPSD in AD. And there was no study that evaluated the relationship BT and BPSD in AD. Methods and Results: We evaluated 65 AD patients using demographic data (sex, educational level, age at dementia onset, age at the time of test and duration of illness), BP, cognitive function, existence of BPSD and morphologic features in the brain using MRI (p<0.05). BPSD was be related with BT. Lower educational level was related with BPSD among those with BT (p<0.05). Conclusions: BPSD in AD was related with BT and among those with BT lower educational level was related with BPSD. We considered that brain reserve (BR) and cognitive reserve (CR) were related with BPSD in AD. We concluded that some kinds of BPSD were related with BR and CR and that there is a possibility that heightening CR might prevent BPSD.